“However, if we want to create high streets that truly support healthier, fairer communities, we must also invest in bringing back vital amenities like libraries and community hubs - regulating unhealthy outlets is important, but we also need to create positive alternatives that give people better choices. The Prime Minister’s announcement is progress, but now we need some real ambition."

This success highlights the importance of academic research in tackling some of society’s most pressing challenges. As the government takes steps to empower local authorities, the researchers will continue to work with policymakers, communities and partners across the UK to ensure that high streets can once again thrive as healthy, inclusive spaces.

Professor Zara Hodgson and Professor Jovica Milanović have been elected for their exceptional contributions to their field: pioneering new innovations within academia and business, providing expert advice to government, and fostering a wider comprehension of engineering and technology. 

Zara Hodgson, Professor of Nuclear Engineering and Director of the Dalton Nuclear Institute at The University of Manchester is an internationally renowned expert in nuclear energy policy and research. She has been pivotal in the UK government’s recent interventions to grow the UK’s nuclear fuel production capability, delivering advances for the global net-zero mission, and generating energy security by building resilient supply chains. Zara is the Director of the Dalton Nuclear Institute and a Professor of Nuclear Engineering at the University of Manchester, where she is leading contributions to the national nuclear enterprise through high impact research, education, training and independent advice.

Jovica Milanović, Professor of Electrical Power Engineering at The University of Manchester is internationally recognised for his outstanding contributions to power systems engineering. His research focuses on the probabilistic modelling of power system dynamics, addressing uncertainties in generation, demand, and network topology, and advancing distributed voltage control strategies. He has played a pivotal role in shaping industrial standards through leadership in IEEE and CIGRE task forces, and his work on load modelling has been instrumental in improving peak demand management across UK networks. Professor Milanović also holds leadership positions within the IEEE and senior advisory roles in the electrical power industry.

The new Fellows will be formally admitted to the Academy at a special ceremony in London on 18 November, when each Fellow will sign the roll book. In joining the Fellowship, they will lend their unique capabilities to achieving the Academy’s overarching strategic goal to engineer better lives.   

The group consists of 60 Fellows, nine International Fellows and five Honorary Fellows.They are drawn from every specialism from within the engineering and technology professions and cover sectors ranging from energy and defence to new materials.

 Sir John Lazar CBE FREng, President of the Royal Academy of Engineering, said: “As we approach our 50th anniversary next year it’s a good time to reflect on how much we have achieved. The Academy is built on the foundation of our Fellowship, and that remains as true today as half a century ago. Our story began as a ‘Fellowship of Engineering’ of 130 Fellows including such pioneers as Air Commodore Sir Frank Whittle, Lord Hinton of Bankside and Sir Ove Arup, driven by the support of HRH The Prince Philip, Duke of Edinburgh.

“Today’s cohort join a community of around 1,700 of some of the most talented engineers and innovators in the UK and around the globe. Their knowledge and experience make them uniquely well placed to tackle the biggest challenges facing the world, and our determination to advance and promote excellence in engineering remains undimmed.” 

Further information about the new Fellows can be found on the

The Ganges, a lifeline for hundreds of millions across South Asia, is drying at a rate scientists say is unprecedented in recorded history. , shifting monsoons, relentless extraction and damming are pushing the mighty river towards collapse, with consequences for food, water and livelihoods across the region.

For centuries, the Ganges and its tributaries have sustained one of the world’s most densely populated regions. Stretching from the Himalayas to the Bay of Bengal, the whole river basin supports over 650 million people, a quarter of India’s freshwater, and much of its food and economic value. Yet new research reveals the river’s decline is accelerating beyond anything seen in recorded history.

In recent decades, scientists have documented across many of the world’s big rivers, but the Ganges stands apart for its speed and scale.

In a , scientists reconstructed streamflow records going back 1,300 years to show that the basin has faced its worst droughts over the period in just the last few decades. And those droughts are well outside the range of natural climate variability.

Stretches of river that once supported year-round navigation are now impassable in summer. Large boats that once travelled the Ganges from Bengal and Bihar through Varanasi and Allahabad now run aground where water once flowed freely. Canals that used to irrigate fields for weeks longer a generation ago now dry up early. Even some wells that protected families for decades are yielding little more than a trickle.

Global climate models have failed to predict the severity of this drying, pointing to something deeply unsettling: human and environmental pressures are combining in ways we don’t yet understand.

Water has been diverted into irrigation canals, groundwater has been pumped for agriculture, and industries have proliferated along the river’s banks. More than a thousand dams and barrages have radically altered the river itself. And as the world warms, the monsoon which feeds the Ganges has grown increasingly erratic. The result is a river system increasingly unable to replenish itself.

Melting glaciers, vanishing rivers

At the river’s source high in the Himalayas, the Gangotri glacier has retreated in just two decades. The pattern is repeating across the world’s largest mountain range, as rising temperatures are melting glaciers faster than ever.

Initially, this brings . In the long-run, it means far less water flowing downstream during the dry season.

These glaciers are often termed the “water towers of Asia”. But as those towers shrink, the summer flow of water in the Ganges and its tributaries is dwindling too.

Humans are making things worse

The reckless extraction of is aggravating the situation. The Ganges-Brahmaputra basin is one of the most rapidly depleting aquifers in the world, with water levels falling by . Much of this groundwater is already contaminated with arsenic and fluoride, threatening both human health and .

The role of human engineering cannot be ignored either. Projects like the in India have reduced dry-season flows into Bangladesh, making the land saltier and threatening the Sundarbans, the world’s largest mangrove forest. Decisions to prioritise short-term economic gains have undermined the river’s ecological health.

Across and West Bengal, smaller rivers are already drying up in the summer, leaving communities without water for crops or livestock. The disappearance of these smaller tributaries is a harbinger of what may happen on a larger scale if the Ganges itself continues its downward spiral. If nothing changes, experts warn that millions of people across the basin could face within the next few decades.

Saving the Ganges

The need for urgent, coordinated action cannot be overstated. Piecemeal solutions will not be enough. It’s time for a comprehensive rethinking of how the river is managed.

That will mean reducing unsustainable extraction of groundwater so supplies can recharge. It will mean environmental flow requirements to keep enough water in the river for people and ecosystems. And it will require improved climate models that integrate human pressures (irrigation and damming, for example) with monsoon variability to guide water policy.

Transboundary cooperation is also a must. India, Bangladesh and Nepal must do better at sharing data, managing dams, and planning for climate change. International funding and political agreements must treat rivers like the Ganges as global priorities. Above all, governance must be inclusive, so local voices shape river restoration efforts alongside scientists and policymakers.

The Ganges is more than a river. It is a lifeline, a sacred symbol, and a cornerstone of South Asian civilisation. But it is drying faster than ever before, and the consequences of inaction are unthinkable. The time for warnings has passed. We must act now to ensure the Ganges continues to flow – not just for us, but for generations to come.

, Leverhulme Early Career Fellow, Geography,
This article is republished from under a Creative Commons license. Read the .

Working with colleagues at Manchester St Mary’s Hospital and the University of Malaysia, the researchers used mathematical modelling to understand how the cord’s unique twisted shape affects the way oxygen, nutrients and heat are exchanged before birth.

The study, published in the , found that the spiral design of the blood vessels in the cord appears to affect the exchange of oxygen and heat, minimising the risk of heat and oxygen being lost, helping to keep babies’ temperature and oxygen levels stable before birth.

Although the umbilical cord is essential to life, scientists still know little about how its complex coiled structure contributes to its function. These new findings shed light on an overlooked but vital process.

Complications linked to the placenta and umbilical cord, such as fetal growth restriction and pre-eclampsia, affect around 10% of pregnancies in the UK, yet remain poorly understood.

The researchers hope their work will pave the way for further studies on abnormal cord structures, such as cords that are too loosely or tightly coiled, which are known to be associated with complications during pregnancy.

Paper details:

Journal : Journal of the Royal Society Interface

Full title: A functional shunt in the umbilical cord: the role of coiling in solute and heat transfer

DOI:

The image from this research was also chosen as the journal's issue cover: 

The project, supported by a £3 million grant from the Gates Foundation, will develop national-scale irrigation mapping data and capacity in three countries – Kenya, Ethiopia, and Nigeria – between September 2025 and August 2029.

Expanding and improving irrigation access is vital for climate adaptation and food security across Sub-Saharan Africa (SSA). Yet, most SSA countries lack up to date or reliable information about existing irrigation systems, leaving governments and development actors limited in their ability to target interventions to improve irrigation access, evaluate outcomes of investments, and ensure development is both sustainable and equitable.

The new project – IrrEO: Irrigated Area Mapping Tool Development and Deployment – will leverage advances in Earth Observation (EO) imagery and artificial intelligence algorithms, working with national partners in the three focal countries to co-develop a set of data products, algorithms, and software that enable high-resolution mapping of irrigated croplands both now and into the future.

The project will also work with local research teams to use new irrigation mapping data and tools to understand the barriers and opportunities for irrigation development, highlighting investment strategies that deliver better results for small-scale farmers.

Another key goal is to strengthen the capacity of government agencies and development partners across Sub-Saharan Africa to apply advanced mapping approaches in national irrigation planning. Over four years, the team will conduct training workshops and participatory design session to help overcome barriers to adopt of EO methods and tools in irrigation decision-making and policy.

The University team brings together interdisciplinary expertise in remote sensing, agricultural sustainability, rural development, and data justice. Alongside , the other Manchester team members include , Senior Lecturer in Physical Geography from the School of Environment Education and Development (SEED) and co-lead of MERI’s newly launched Land and Resource Futures Initiative – and , Senior Lecturer in Socio-Environmental Systems in the Global Development Institute (GDI).

The report calls for urgent reforms, including:

Faster approvals – cutting the red tape that slows NHS trial delivery.
Flexible design – letting participants choose between home visits, clinic appointments or online check-ins.
Specialist centres – building dedicated hubs for mental health trials inside major NHS Trusts.
Smarter promotion – using social media campaigns and testimonials to boost awareness and trust.

Despite the surge of private providers, the NHS still has key advantages. It can draw on huge, reliable patient datasets and long-standing doctor-patient relationships that private firms cannot match. This helps ensure trials include a diverse mix of people – and prevents the problem of “professional patients,” which industry leaders say can account for up to 30% of participants in US depression trials.

The study was supported by the UK Government’s Office for Life Sciences and the National Institute for Health and Care Research.

As more countries and regions introduce stronger privacy protections, the study raises questions about how smaller financial institutions will cope with the cost of compliance. While consumers may benefit from improved protection, the financial burden may be felt most by smaller banks, which could in turn affect the services they provide.

The research provides valuable insights for policymakers, banks and the public. It underlines that the debate over data privacy is not only about regulation but also about competition, trust and the future of banking in the digital age.

John will sit on the University Executive with responsibility for driving The University of Manchester’s strategic agenda across civic engagement and innovation, working in partnership with local, regional and national stakeholders, and across the full breadth of our university community.

John brings extensive experience in strategic leadership across higher education, national and local government, and industry. In his current role as Associate Vice President for Major Special Projects at The University of Manchester, he has played lead roles in delivering key initiatives, including the establishment of the UK’s , the relocation of the UK Biobank to the Oxford Road Corridor, and the creation of the Turing Innovation Catalyst. He was the University’s lead in establishing Sister, the 20-year project to build a new innovation district on the former North Campus.

In 2024, he co-led the University’s Regional Innovation Review and played a pivotal role in the creation of , the University’s new dedicated innovation arm launched to unlock the University’s full potential as the region’s largest innovation asset and drive inclusive growth regionally and nationally. Recently he has also been instrumental in developing our burgeoning relationship with Cambridge which is pioneering a new model of place-to-place collaboration to drive inclusive economic growth for the UK.

Professor Duncan Ivison, President and Vice-Chancellor of The University of Manchester, said: “We want to be one of the leading 21st Century civic universities in the world. A significant part of that vision is to be a powerhouse for innovation and strategic partnerships in our city region, the UK and globally.

“John brings a strong track record of civic engagement and developing innovative programs and policies that have contributed to creating opportunities for our region and beyond. To further this ambition, it is vital that we work with our partners and communities to meet the challenges that they face and I’m excited that John is set to play a leading part in this.”

Professor John Holden, Vice-President for Civic Engagement and Innovation, said: “I am delighted to have been appointed Vice-President for Civic Engagement and Innovation. With these two critical agendas set to be at the heart of our new 10-year strategy launching in October, this is a pivotal moment for the University and an exciting time to take on a role focused on driving its delivery.

“Our University has a proud tradition of working in partnership with our city and region, recognising that our success and the success of our region are inextricably linked. By strengthening our collaborations with industry, civic partners, and communities we can accelerate research into real-world impact, help our students unlock their full potential, and develop solutions to the major challenges that face our region and the world.

“As one of the North of England’s most significant innovation assets, the University has the scale, capabilities, and global reach to play a central role in driving inclusive economic growth and prosperity not just for our region but for the whole of the UK.

“I’m looking forward to working with our students, staff, alumni and partners to improve lives and create opportunities locally, nationally and globally — and I look forward to engaging with current and future collaborators about how we can make this happen together.”

Before joining the University in 2020, John spent 15 years in senior strategy and policy roles in Greater Manchester. He was instrumental in shaping the city region’s Mayoral Combined Authority, including the landmark 2014 ‘Devo Manc’ devolution deal and subsequent agreements that transferred significant powers and funding from the UK government to the city region. As head of the Greater Manchester Combined Authority’s Strategy and Research team, he worked with Mayor Andy Burnham, Sir Richard Leese, the late Sir Howard Bernstein and other regional leaders to set and deliver economic growth and public service reform policy.

He has advised national and international organisations on regional policy, including the Department for Business, Innovation and Skills, the Foreign and Commonwealth Office, the European Commission and the Organisation for Economic Co-operation and Development. John is also a Board member of the Rochdale Development Agency, a North West Council Member of the Confederation of British Industry, a member of the Oxford Road Corridor Executive, and a fellow of the Royal Society of Arts (RSA).

John will begin in his new role from 1st October 2025.

“The quality of universal SEL education has significantly improved over the last two decades, meaning new programmes face a higher bar for showing additional impact. This highlights the excellent work already being done in schools to nurture children's mental health," Neil added.

The research also raises questions about whether programmes developed in one country - like Passport, which was originally from Canada - will work the same way in another. Cultural differences may affect how well these interventions work.

The researchers plan to keep studying the data, and looking into whether the programme has any long-term benefits, works better for certain groups of children or is good value for money.

Eviction: A Social History of Rent is available now from .

Research conducted by High Fliers, published via , ranked Manchester second only to Birmingham, and ahead of Nottingham, Warwick and Bristol.

Now in its 21^st year, The Graduate Market is an annual review of the graduate job market, with this year’s report based on research completed in July 2025 with 100 of the UK’s leading graduate employers. The University of Manchester has maintained its second-place ranking from the previous year.

The report cited how the top five universities attracted the most graduate employers in 2024-2025 for locally-run publicity, university career fairs, on-campus employer presentations, careers service promotions, on-campus presentations and university-specific virtual events.

The University of Manchester is consistently ranked highly in national and international rankings, scoring second in the Times Higher Education (THE) University Impact Rankings for 2025 and 53^rd in THE’s overall list.

The University rose this year to 46^th globally and 13^th in Europe in the 2025 Academic Ranking of World Universities (ARWU). It also ranked 35^th in the world and 11^th in Europe in the QS World University Rankings, and 9^th in the QS World University Sustainability Rankings.

Organised in partnership with Rethink Rebuild Society and supported by the Chemists’ Community Fund (Royal Society of Chemistry), 48 children aged nine to 14 visited the University’s state-of-the-art Makerspace facility over three days to take part in a variety of fun and practical experiments, including making batteries out of lemons, testing acidity with natural indicators, and simple filtration experiments.

The initiative is the brainchild of Dr Abdullatif Alfutimie, Senior Lecturer in the School of Chemical Engineering at the University. Dr Alfutimie first came to Manchester from Aleppo in 2009 to pursue postgraduate study before going on to complete his PhD in 2012. But while pursuing his research career, his home city of Aleppo – once one of Syria’s most vibrant cultural centres – was being devastated by civil war.

Staying closely connected to family and friends affected by displacement and the collapse of education, he began to consider how he might use his own expertise to help displaced students regain educational confidence.

Dr Abdullatif Alfutimie, who led the programme, said: “This event wasn't just about science — it was about recognising curiosity, celebrating identity, and creating a sense of belonging for children who often face immense challenges.

"If we need to rebuild our country or even to contribute to improve this country, we need to educate this generation.

“The enthusiasm from the pupils was truly heartwarming - one parent told us that their child couldn't wait to repeat an experiment at home for their siblings.”

The initiative concluded with a Community Celebration Day at Rethink Rebuild Society’s centre in Manchester, welcoming more than 150 children and family members. Each child received a certificate and a take-home chemistry kit to continue their learning at home. A representative from the Royal Society of Chemistry was also in attendance to present the certificates and celebrate the children’s achievements.

Magda van Leeuwen, Volunteer and Engagement Manager for the Royal Society of Chemistry, said: “Chemistry Education for Refugee Students is an important initiative that gives young people who have already experienced a lot in their lives hope and opportunities. Programmes like the one Abdullatif has developed show that chemistry really is for all and can be a catalyst for instilling a lifelong passion in our subject.

“Through the Outreach Fund and with the backing of the Chemists’ Community Fund, the RSC is committed to supporting projects that give more people the opportunity to get hands-on scientific experiences. We are proud to have played a small part and want to applaud Abdullatif and his colleagues for their hard work in putting together such a practical and engaging experience for the participants.”

The University of Manchester is recognised as a University of Sanctuary, working to make the University a welcoming and safe place for refugees and asylum seekers. The University’s commitment to supporting sanctuary seekers is embedded across its three core goals: research, teaching, and social responsibility. The city of Manchester is also a City of Sanctuary, part of the . The University works closely with the organisation to help its aim of making Manchester a place that is open and fair. 

Read more about Abdullatif’s initiative on the

Established in 1945, COEH is the UK’s oldest and one of the world's earliest centres for occupational health research and education. Its foundation lies in Manchester's industrial history, particularly the cotton industry, with early studies addressing respiratory diseases and lead exposure. 

The annual honours , the first Professor of Occupational Medicine (1945–1964). The Centre’s subsequent leaders have each contributed to its growth and enduring reputation: Tommy Scott focussed on research on bladder cancer and hearing loss; Tim Lee broadened the scope to areas such as occupational asthma and lead poisoning, and introduced distance learning; Nicola Cherry expanded the department further with research into neurotoxicity and Gulf War Syndrome, launching the Occupational Disease Ascertainment Network (ODIN) network; and Raymond Agius strengthened environmental health research and online education, securing long term funding for the future. 

Current lead, Professor Martie van Tongeren, has transformed the Centre into an interdisciplinary centre offering innovative undergraduate and postgraduate training, attracting students from around the world. Working in collaboration with and the , COEH’s research spans global occupational and environmental health, health inequalities, climate change and health, digitalization and AI, as well as traditional occupational hazards. The Centre is also actively engaged with regulatory bodies, and its balance of basic and translational research supports policy makers. 

As COEH enters its ninth decade, the centre continues to build on its founders’ pioneering work while adopting new approaches to train practitioners and address emerging challenges. Through interdisciplinary collaboration with partners COEH remains committed to social responsibility and reducing health inequalities both in the UK and worldwide, continuing to make a significant impact. 

Professor van Tongeren commented: “I am proud and honoured to be part of the Centre for Occupational and Environmental Health, continuing the legacy begun by Prof Ronald Lane 80 years ago. As new challenges like AI emerge and longstanding ones like silicosis persist, our mission to protect worker health through research and teaching remains vital. I’m confident COEH will continue to lead the way.”

80^th anniversary event 

COEH invites colleagues and guests to commemorate 80 years of pioneering research and education at The University of Manchester on the afternoon of 1 October. The event will bring together past and present staff, students, and guests to honour the Centre’s legacy and explore future progress in occupational health.  

The programme will include: 

• Lightning talks showcasing key achievements and ongoing research initiatives 
• Forward-looking panel session to explore challenges and opportunities in occupational health 
• The , presented by Professor Malcolm Sim, former Head of the Monash University Centre for Occupational and Environmental Health in Australia 
• Closing reception  

2025 Lane Lecture 

While UK occupational health research, including at COEH, now focuses more on stress and mental health, traditional risks such as occupational respiratory disease continue to be a key priority. The Centre has, in recent years, led efforts to address the dangers of artificial stone (used frequently in kitchen worktops and bathrooms) as workers without proper controls can develop accelerated silicosis—a serious lung disease affecting even young individuals. 

Professor Malcolm Sim played a lead role in research and advisory activities to address the silicosis epidemic in Australia among stonemasons working with artificial stone. In this year’s Lane Lecture, Professor Sim will explore artificial stone silicosis further through his talk, ‘The Artificial Stone Silicosis Epidemic: Lessons Learned for More Effective Prevention’. 

where you can also find a detailed programme.

The research, titled Right on Cue? Category-Switching in Online Marketplaces, is published in the .

The peer reviewed meta-analysis of 16 studies involving 71,336 patients from the US, UK, and the Netherlands published in the today (10/09/25), is a wake-up call to policy makers grappling with escalating numbers affected by the disease. 

“Our study provides evidence of significant disparities in telemedicine use for type 2 diabetes among men, black communities and those with lower levels of education,” said Nawwarah Alfarwan, a PhD researcher and lead author of the study. 

“These groups already face many challenges in accessing essential healthcare services. 

“Every 10 seconds, somebody dies from diabetes-related complications worldwide, most of whom have type 2 diabetes, so policymakers  really need to think about how to improve access to this crucial form of healthcare.” 

Telemedicine has revolutionised the management of type 2 diabetes in primary care by improving access to healthcare services, and consequently health outcomes. 

Comprising a range of technology including virtual consultations, wearable devices, mobile health apps and other technologies, health services have successfully used it as a response to increasing prevalence of the disease. 

Data from 5 studies comprising 59, 609 patients showed patients with higher education levels had 68.1% greater odds of using telemedicine than those with lower education levels. 

The less educated, say the researchers, have lower levels digital and health literacy, and be more likely to have concerns about trust and privacy. 

Ten of the studies, comprising 68,355 patients, showed female patients had a 5% higher chance of using telemedicine than men.

The difference can be explained, say the researchers, by women being more actively engaged with healthcare services not only for themselves but also their family.

Existing epidemiological evidence, they add, suggests men’ have lower help-seeking behaviour, stronger preferences for in-person consultations, or lower levels of digital health literacy.

Five of the studies showed that compared to white patients, black patients were less 45% likely to use telemedicine.

Many people within black communities, the researchers argue, have limited access to digital infrastructure, mistrust in healthcare systems, language barriers, and inadequate insurance coverage or digital literacy support.

And 10 of the studies comprising 47 927 patients showed older patients were 2.1% less likely to use telemedicine than younger patients.

Co-author Professor Maria Panagioti , also from The University of Manchester,  added: “For patients with type2 diabetes, we show the extent of the digital divide in certain demographics, especially those from minority backgrounds.

“Lack of affordable access to computers, smartphone, and lower levels digital and health literacy all contribute to these inequalities.

“By understanding these disparities and addressing the underlying factors, policymakers could make more inclusive and effective telemedicine interventions.

“They should also  consider targeted strategies to improve engagement among men, such as awareness campaigns and tailored interventions.”

• The paper is Demographic and Socioeconomic Disparities in Telemedicine Utilisation Among Individuals with Type 2 Diabetes in Primary Care: Systematic Review and Meta Analysis is published in the  

About the Richard Whipp Lifetime Achievement Award

The Award is made in memory of Professor Richard Whipp, an outstanding scholar in the field of business and management and former Chair of BAM. It specifically recognises a career within the management field where the beneficiary will have done one or more of the following: enhanced a field of study, founded or effectively led a major national/international academic initiative, or provided unusually effective service to a major professional institution and/or the Academy.

Professor Hodgkinson’s Reflections

Said Professor Hodgkinson: “I’m delighted and humbled in equal measure, to have received this prestigious award, in recognition of my various contributions to research, BAM, and the wider management research community, over the course of the past 40 plus years.”

A Legacy of Achievement

Professor Hodgkinson was made a Fellow of BAM in 2001 and received the BAM Medal for Research in 2021. He is pictured receiving the Richard Whipp Award from Richard’s widow Anne Whipp.

”The evidence is strong, and it should be part of the conversation on how we help vulnerable young people not just survive, but thrive," Neil added.

The experts say the next step is to study the programme in more detail, looking at whether the benefits last long term and whether it can also help reduce loneliness.

The study was funded by PBE, with wider support from the , The National Lottery Community Fund, and the Greater Manchester Combined Authority.

The festival will take place from 11am – 4pm. For more information, visit . 

The study also highlights the deep impact of colonial history, showing how the French Empire shaped today’s ideas about identity, and how some communities - like those with Indian roots - have been left out of the national story.

This research is one of the first studies to centre the voices of French citizens of Indian descent, a group rarely studied in academic or public discussions about French imperial history. It is especially relevant today as France - and many other countries - grapple with their colonial past and while having increasingly diverse populations.

The final version of the tool, called INSPECT-SR, is now published on the pre-print server . 

It was developed by a worldwide collaboration of more than 150 integrity and health research experts, led by Dr Jack Wilkinson from The University of Manchester 

Funded by the National Institute for Health and Care Research (NIHR), it was developed in collaboration with the University of Colorado Anschutz Medical Campus and Cochrane, a not-for-profit organisation which is the world’s leading publisher of health systematic reviews. 

Some of the studies are subject to critical but honest errors, but many appear to be fraudulent.

Concerns are growing over the increasing numbers of problematic high-level summaries of the research evidence from randomised controlled trials , known as systematic reviews. 

In 2023 alone, over 10,000 research papers issued globally were retracted by journals according to an analysis by , many of which used evidence from problematic RCTs. 

Dr Wilkinson warns problematic RCTs  can result in medical research potentially being compromised, drug development hindered and promising academic research jeopardised. 

INSPECT-SR is designed to root out problematic RCTs which publish faked or manipulated data or have Inadvertently made critical errors. 

Some, written for a fee by outfits known as “paper mills”, are entirely fabricated. 

The tool guides users through a series of 21 checks, grouped into 4 domains:

• Post publication notices which express concern and retractions.
• conduct, governance, and transparency
• text and figures
• data discrepancies and statistical errors.

One of the most well-known examples of problematic RCT research was around claims the drug Ivermectin, hailed as a miracle drug that would save the lives of people with severe COVID-19. 

However, some of the trials used to make the Ivermectin claims appear to have been fabricated, according  health authorities in the . Subsequent high-quality trials suggested little or no benefit. 

In another example , the National Institute for Health and Care Excellence (NICE) reversed recommendation for a device called a fetal pillow, developed to assist caesarean sections, following the retraction of three clinical studies supporting it. 

According to an article in : An International Journal of Obstetrics & Gynaecology, a trustworthiness assessment may have prevented the use of the evidence in the NICE guideline, as it contained statistical anomalies. 

And trustworthiness concerns were also identified in a group of trials around the use of  CBT and exercise to combat spinal pain. The trials had substantial impacts on clinical practice guidelines. Several have now been .

Dr Wilkinson said: “When a systematic review is carried out, it includes all randomised  controlled trials on a given topic.

“But historically, there has been no way to identify fraudulent or otherwise problematic RCTs, meaning that these studies are inadvertently included in systematic reviews.

“This is a big problem, as systematic reviews are very influential - they inform health guidelines for example.

“Most fraudulent RCTs are produced by individual researchers rather than commercial paper mills, but with the  advent of  AI I fear  this is likely to become more of a problem in the future.”

He added: “Academic papers are often assessed for quality before they are published. But reviewers do not ask the more fundamental question of whether the evidence they are reading is even genuine..

“But we anticipate that INSPECT-SR will become the standard for assessing trustworthiness of RCTs, especially as it has been created withCochrane for use in their systematic reviews of health interventions.

“However, it’s important to stress that our tool is not merely a test for fraud and misconduct-  though clearly many problematic studies are examples of that.

“It also tests for critical errors which is why our priority is to  determine if a clinical trial should be used to guide healthcare decisions.

“Work is ongoing to develop more automated systems -  perhaps using AI-  to assist with this process. In the future, we hope to expand our work  to detect problems in other forms of research studies, not just clinical trials.”

• The paper INSPECT-SR: a tool for assessing trustworthiness of 1 randomised controlled trials is available on the print server https://doi.org/10.1101/2025.09.03.25334905

“The recipients of this year’s medals and awards have all made outstanding contributions to science and its applications for the benefit of humanity,” said Sir Adrian Smith, President of the Royal Society. “They have done so through by furthering our understanding of the processes that govern the world around us, changing the practices of academia to build a more robust and inclusive research environment, and engaging new audiences. I offer my congratulations to all the 2025 recipients.” 

Our third new Fellow is Professor of Urban Economics & Real Estate Anupam Nanda, an award-winning expert in the economics of property markets, urban and regional dynamics, real estate finance, investor sentiment, cross-border investment, ESG issues, and the role of technology in real estate. A prolific researcher, his papers feature in top journals such as Journal of Urban Economics, Real Estate Economics, Regional Studies, and Energy Economics. Alongside his academic research, he works with policymakers and industry to develop solutions for sustainable, resilient and fair urban and housing systems.

“I am pleased to be nominated to join the Academy and contribute to its crucial work in promoting the role of social sciences in my field and across other related fields,” said Anupam. “I look forward to working with other fellows of the Academy.”

President of the Academy, Will Hutton FAcSS, said, “It’s a pleasure to welcome more leading social scientists to the Academy’s Fellowship. Their research and practical applications have made substantial contributions to social science and wider society in a range of areas, and we look forward to working with them to promote further the vital role the social sciences play in all areas of our lives.” 

The book covers examples from around the world - from Brazil to China and South Africa to Norway - across all levels of society from grassroots street activists in California right up to global negotiations. The volume also tackles a wide range of policy areas and sectors including the fossil fuel industry, financial and insurance businesses and electricity companies.

It is available now, and free to read and download from .

’, published to mark the Centre’s 25th anniversary, looks back at the Tyndall Centre’s own energy scenarios, alongside more than 80 others produced in the 2000s. The study found that while most scenarios assumed some level of reduction in energy demand, only one -  Tyndall Centre’s “Red” scenario - came close to predicting the UK’s actual energy demand in 2022.

The researchers say this mismatch reveals that early scenarios often focused on untested technologies while overlooking practical and proven ways to reduce energy use, such as improving public transport, insulating homes, and reducing air travel.

They identified that these modelling choices often influenced policy debates, with optimism about new technologies often overshadowing everyday solutions, potentially limiting the scope of decarbonisation deemed possible by policymakers.

 By comparing the envisioned futures with the UK energy system changes that actually emerged, the authors show where foresight was limited, where assumptions proved overambitious, and where genuine transformation was underestimated.

The report also reflects on two decades of Tyndall Centre’s research. Starting with the Royal Commission’s 60% carbon cut target by 2050, the Tyndall Centre helped bring carbon budgets to the centre of UK climate policy and highlighted the need for action across all sectors, including aviation and shipping,.

The authors argue that energy scenarios aiming to support an urgent reduction in greenhouse gas emissions, must explore a wider range of options, with greater focus on proven solutions such as efficiency, lifestyle change, and equity. Doing so would open up more options for policymakers to deliver on their climate ambition, reduce reliance on unproven technologies, and align the UK’s energy pathways more closely with climate science.

Decarbonising the UK revisited is being launched at the Tyndall Centre’s 25^th Anniversary Conference at the University of East Anglia (UEA) on Monday, 8 September. Our Critical Decade for Climate Action is a major meeting for 300 researchers from 20 countries.

The report is part of a wider project at Tyndall Centre that explores how energy scenarios influence policy and what lessons can be drawn halfway through this critical decade for climate action.

Read the full report

In a new review, published in the journal today, the researchers have examined the current scientific research on how tiny plastic fragments – called micro and nanoplastics – enter the air, where they come from, and the mechanisms that transport them across vast distances.

The study reveals significant gaps in knowledge and understanding of airborne plastic pollution, driven by inconsistent measurement techniques, limited data, oversimplified simulations, and gaps in understanding atmospheric cycling mechanisms.

One key uncertainty is the scale of plastic entering the atmosphere. Current estimates vary wildly - from less than 800 tonnes to nearly 9 million tonnes per year - making it difficult to assess the true global impact. It also remains unclear whether the dominant contributors are land-based, such as road traffic, or marine based, such as sea spray.

Such large uncertainties raise the concern that airborne plastics, which pose potential risks to human and environmental health, may have a more extensive presence and influence than previously captured by current monitoring and simulation systems.

Each year, the world produces over 400 million tonnes of plastic, with a significant proportion ending up as waste. Over time, these plastics breaks down into microscopic particles called microplastics (less than 5mm) and nanoplastics (smaller than 1 micron), which are increasingly being found in the air we breath, oceans and soil. These particles can move thousands of miles within days and have even remote regions like polar ice zones, desserts and remote mountain peaks.

While our understanding of the problem has grown rapidly, limited real-world data, inconsistent sampling methods, and computer models that oversimplify how plastic behaves in the air, means that key questions remain unanswered.

To address these concerns, the authors are calling for future research efforts to focus on three critical areas:

• Expanding and standardising global observation networks
• Improving and refining atmospheric modelling
• Harnessing the power of artificial intelligence (AI)

They say this integrated approach could transform how we understand and manage the plastic pollution crisis.

Full title: A Review of Atmospheric Micro/Nanoplastics: Insights into Source and Fate for Modelling Studies

Journal: Current Pollution Reports  

DOI: 10.1007/s40726-025-00375-5

Link:

Two peer reviewed studies led by University of Manchester researchers across 28 NHS maternity units are published  today in the journals BMJ Open Quality  and BMJ Quality and Safety.

The BMJ Open Quality   paper showed 89% of women reported positive antenatal care and 86% had positive labour experiences.

However, the data from online surveys with 1,140 women and 633 healthcare professionals  - carried out in 2023-  also showed concerns around poor communication, lack of personalised care, staff shortages and delays still persist.

The Saving Babies’ Lives Care Bundle (SBLCB) was introduced in England from 2015 as the Government’s response to a stillbirth rate that was comparatively higher than many western countries.

SBLCB has evolved through three versions in 2016, 2019, and 2023, each building on the last to improve maternity care and reduce perinatal mortality across England.

The SBLCB evaluation- of version 2 -  found it had been successfully rolled-out in the majority of NHS maternity providers and that midwives and frontline staff have a pivotal role in implementing it.

Women’s positive experiences were linked to feeling listened to, being involved in decision-making, effective communication and continuity of care.

They encountered staff, the researchers found, who acknowledged their history and made them feeling able to ask questions.

However their negative experiences often stemmed from poor communication and lack of personalised care, making them feel dismissed, especially when expressing concerns about reduced fetal movement and during labour.

Some of the women who had a negative labour or birth experience also reported disorganised and inconsistent care, staff shortages, lack of beds and poor pain management which left them feeling neglected.

Poor communication between staff made care feel disjointed and was further hindered with changes to electronic notes, they reported.

Risk factors was not always communicated effectively and women were often given no choice in their treatment which meant they felt threatened or frustrated.

Alexander Heazell, is Professor of Obstetrics at The University of Manchester, Honorary Consultant Obstetrician at St Mary’s Hospital, and Director of the Tommy’s Stillbirth Research Centre.

He said: “We analysed a total of 1,071 women’s written responses about their antenatal care, of which 89% reported a positive experience. 86% had positive experience of labour.

“So much progress has been made  in terms of their experiences around feeling listened to and reassured, feeling in control of decision-making and  encounters with staff and care.

“Our data suggest that elements of the SBLCBv2 are increasingly embedded in maternity care, but refinements are still needed.

“This will  address variation in practice between units and to support effective communication between health care professionals and service users to balance standardised clinical practice with personalised care.

A second paper published in BMJ Quality and Safety examined the qualitative  experiences of the women.

Lead author Dr Holly Reid, also from The University of Manchester, said: “Our paper found that having a trusting relationship with maternity care providers is of paramount importance to achieve positive and safe maternity experiences for women.

“Trust was built through consensus among the care team, making sure the partner was involved in discussions around care and continuity of carer.

“When women were not listened to or believed by healthcare professionals during labour and birth, this resulted in frightening experiences for women and their safety being put at risk.”

Professor Heazell added: “However, there is still work to do. Service users need to feel heard, involved in and reassured by their care. To this end, the communication between health care professionals and service users is critical.

“We suggest maternity staff may benefit from additional training to discuss the reasons for and results of interventions to reduce the risk of pregnancy complications.

“This will need to be combined with effective communication skills to ensure that service users receive information to make an informed choice, ensuring they retain agency and perceived control.

“And that will enable the core recommendations of SBLCBv2 to be personalised to individual service users, promoting safe maternity care and improved maternity experience.”

Examples of representative anonymised quote from service users:

All testing done efficiently, staff were continually informing us about the decisions they were making, we felt well taken care of”

“I felt really dismissed by the midwives when I kept saying the baby wasn’t moving and I didn’t feel well

“All testing done efficiently, staff were continually informing us about the decisions they were making, we felt well taken care of”

“While yes I got growth scans nothing was ever explained and I wasn’t able to ask any questions”

“The staff were attentive and provided me with all the information I required. This was offered and also given 24 hours a day with no bias.”

“The administration side of things was not great. I was forgotten about on numerous occasions. Letters were sent out with appointment dates that didn’t exist. I would turn up and people weren’t expecting me.”

• The paper Evaluating the implementation of the Saving Babies Lives Care Bundle Version 2 from Service User and Health Care Professionals’ perspectives: A Questionnaire ����Ů��  is published in BMJ Open Quality  DOI:  bmjoq-2025-003456
• The paper Service users’ experiences of maternity care in England informed by the Saving Babies’ Lives Care Bundle Version 2: A reflexive thematic analysis to be published in BMJ Quality and Safety is  published in BMJ Quality and Safety  DOI: 10.1136/bmjqs-2025-018582

The work by Professors Jo Dumville and Nicky Cullum on the most effective types of compression treatments is good news for the hundreds of thousands of patients affected by venous leg ulcers every year,  costing the NHS tens of millions of pounds. 

Venous ulcers are a common long-term condition which adversely affect people's quality of life; nurses deliver the majority of care, which takes the form of compression therapy as a first-line treatment. 

According to the NHS National Wound Care Strategy Programme, venous leg ulcers account for 60% to 80% of all leg ulcers. 

However, the abundance of different compression treatments and heavy product promotion by the wound care industry makes it difficult for nurses to decide, with patients, on the course of treatment that is most clinically effective and offers the most value to the NHS. 

The guidance - known officially as a “Late Stage Assessment" -  is set to change that by providing crucial information to nursing staff on the most effective types of compression. 

It will also help NHS commissioners and procurement specialists give healthcare professionals access to a range of the most appropriate compression products to ensure their affordability to the NHS. 

According to the researchers’ evidence, the clinical effectiveness of two-layer compression hosiery and two-layer and 4-layer bandages is similar, while compression hosiery is more cost-effective than bandages. However, compression wraps are less clinically and cost-effective.

Professor Cullum was first asked to review the research evidence on leg ulcer management by the then Department of Health (now the Department of Health and Social Care) in 1989.

Working with Professor Dumville, they have been analysing and publishing the evidence in Cochrane and other systematic reviews, and have worked to fill knowledge gaps by doing new randomised controlled trials and other relevant studies.

A Cochrane systematic review is a rigorously conducted, independent review of research evidence on the effects of healthcare interventions, published by Cochrane, a global, not-for-profit organisation.

The latest randomised controlled trial, led by Professor Dumville will have further important implications for care and is likely to be published later in 2025 or early 2026.

Professor Dumville said: ‘I am delighted that our NIHR-funded research has delivered high-quality and relevant evidence on compression therapy for venous leg ulcers.

“The contribution of these findings to NICE’s late-stage assessment underscores the importance of NIHR studies like VenUS 6 in strengthening the clinical evidence base in wound care and informing national recommendations that support best practice in patient care.”

Professor Cullum said: “This is the first time there has been a piece of NICE guidance on compression therapy for venous leg ulcers.

“It feels like something of a culmination of all the work Jo Dumville and I have been doing for decades, so we are delighted it has culminated in some national guidance which will help nurses and patients arrive at informed decisions.”

• See Professor Cullum’s Lockdown Lecture  where she talks about her work on leg ulcers and her with Jude Johnson.

Located around 3,400 light-years away in the constellation Scorpius, the Butterfly Nebula is one of the best studied planetary nebulae. Its ‘wings’ of glowing gas were previously but Webb’s new observations, published in today, go even further, uncovering hidden structures and finally pinpointing the nebula’s elusive central star.

Planetary nebulae like the Butterfly form when stars heavier than the sun reach the end of their lives, casting off their outer layers of gas and dust. The Butterfly Nebula is what astronomers call a bipolar nebula, meaning that it has two lobes of gas that spread in opposite directions to form the ‘wings’ of the butterfly. At its centre, a dense band of dusty gas called the torus, which poses as the butterfly’s ‘body’. This structure energises the nebula and may be responsible for its insect-like shape by preventing gas from flowing evenly in all directions. 

Using James Webb’s , scientists have now been able to see through this dusty torus for the first time, providing an unprecedented view of its complex structure.

By combining images at many different wavelengths with complementary data from the Atacama Large Millimetre/submillimetre Array in Chile, the international team of researchers, including from The University of Manchester, discovered  the butterfly’s central star, one of the hottest ever found in our galaxy, with a scorching surface temperature of around 220,000 Kelvin.

Although this intense heat powers the nebula’s colourful glow, earlier telescopes lacked the sensitivity and resolution needed to see through the thick layer of dust, making the star impossible to detect at visible wavelengths.

Professor Albert Zijlstra, a co-author of the paper from The University of Manchester, said: “This is an extraordinary discovery. We’re looking at one of the hottest stars ever found - an object so elusive that even Hubble couldn’t detect it for decades. Thanks to JWST, we’ve finally uncovered it, concealed within its own dense shroud of dust.

“Surrounding the star is a massive dark torus, the heaviest ever observed around such an object, containing more material than our own Sun. Even Webb can’t fully pierce through it. Inside, the environment is sheer chaos; powerful radiation and stellar winds tearing into the surrounding cloud. It’s unlike anything I’ve ever seen.

“Most planetary nebulae appear graceful and symmetric, but this one is still at the beginning of its transformation – it’s more like a butterfly struggling out of its cocoon than the elegant shapes we’re used to seeing.”

The Webb data revealed that the torus is composed of crystals similar to quartz as well as unusually large grains of dust, suggesting they have been growing for a long time. Outside the torus, the team observed jets of iron and nickel blasting away from the star in opposite directions, along with a multilayered structure made up of different atoms and molecules.

Perhaps most intriguing was the discovery of carbon-based molecules known as polycyclic aromatic hydrocarbons, or PAHs. On Earth, these molecules are found in smoke from fires or even burnt toast – but they have never before been seen in an oxygen-rich planetary nebula. The team believes the PAHs may form when a bubble of stellar wind bursts into the surrounding gas.

The finding provides an important glimpse into the details of how these molecules form.

***

Journal:

Full title: The JWST/MIRI view of the planetary nebula NGC 6302 – I. A UV-irradiated torus and a hot bubble triggering PAH formation

DOI:  

Link:  

Intended to fund future medical and music students in need of support, Dr Weir hopes the bursaries will help others experience the world-class education at Manchester she has benefitted from over her long career.

Dr Weir has an extensive background in pharmacology, joining Manchester after completing her bachelor’s degree at the University of Strathclyde, Glasgow. While she initially wanted to study medicine, she didn’t qualify for a grant.

For Sheila, this outcome paved the way to completing a PhD in Pharmacology at Manchester in 1985. Her work contributed to the eventual spark of interest worldwide in the field of potassium channels and their modulation by drugs.

After leaving academia, Sheila spent 30 years in drug development at the one of the world’s leading pharmaceutical companies. But her keen interest in learning continued as she taught at ETH Zürich and the University of Lausanne in Switzerland along the way.

Dr Weir said of her donation: “The greatest gift I can give is making a difference in the life of another human being. Especially if that person is young, from an underprivileged background and dreams of attending University."

Professor Ashley Blom, Vice-President and Dean of the Faculty of Biology, Medicine and Health at The University of Manchester said: “We are honoured by Dr Weir’s forward-thinking commitment to support Manchester’s future music and medical students.

“Her generosity will continue Manchester’s rich history of musical vibrance and medical excellence, enabling talented individuals to pursue their ambitions regardless of the obstacles they may face. We thank Dr Weir for her unwavering faith in our students and for helping to make their dreams a reality.”

In addition to funding medical bursaries, the musical bursaries reflect Dr Weir’s passion for music, which has been a constant in her life from an early age.

Amy Harris, Legacy Officer at The University of Manchester said: “It has been a pleasure to work with Dr Weir to transform her hopes for the future into tangible support that will shape the lives of students, and their communities, for generations to come.” 

Dr Weir is one of a growing number of alumni, staff and other supporters who have chosen to support the University with a legacy gift. Donors are welcomed to the , which recognises their generosity through a programme of special events and communications.

For more information about leaving a gift in your Will, visit the University’s website.

The energisation of Medebridge, located in Ockendon, Essex, means that up to 65% of the University’s electricity demand will now be met from exclusive ‘new-to-earth’ renewable infrastructure.

Developed in partnership with leading UK clean energy firm Enviromena, the project is part of a 10-year (CPPA), facilitated by EDF and supported by Inspired PLC, the UK’s leading energy and sustainability advisor. It is the UK’s largest solar CPPA with an educational institution.

The development represents the University’s long-term commitment to sustainability and energy resilience.

Professor Nalin Thakkar, Vice-President for Social Responsibility at The University of Manchester, said: “The University’s new long-term solar power agreement is a landmark moment in our journey to zero carbon. By entering into this corporate Power Purchase Agreement, we are directly supporting the development of new UK renewable energy while significantly cutting our own emissions.

“Universities have a vital role to play in tackling the climate crisis, not just through research and education but by taking bold, practical action. At Manchester, we’re proud to be the only university ranked in the global top ten every year for social and environmental impact in the Times Higher Education Impact Rankings, and we remain determined to lead by example to help create a more sustainable future for generations to come.

“We’re incredibly grateful to our partners, including Inspired, Enviromena and EDF, whose expertise and support have been essential in making this project a reality.”

Lee Adams, Chief Commercial Officer at Enviromena, added: “We’re incredibly proud to see Medebridge go live. It’s our largest and most complex project to date and a major step forward in the UK’s net-zero journey.

“By securing a long-term commitment with a top-tier academic institution, this project proves how large-scale renewables and corporate sustainability can align to deliver real impact.”

The construction of Medebridge commenced in April 2024. Comprising of around 104,000 solar panels across 175 acres (roughly the size of 70 football pitches), the site will generate more than 72 GWh of electricity annually, 80% (58GWh) of which will be purchased directly by the University over the next decade. The move will reduce University carbon emissions by 12,000 tonnes of CO2e each year - enough to power 21,000 homes.

In addition to emission reduction, the site will also create a significant biodiversity net gain. Enhancements to the existing hedgerows and planting of native grassland and wildflower meadow beneath and around the solar arrays will encourage nesting opportunities for wildlife and improved habitat connectivity.

Since the CPPA was agreed, Inspired have supported the Enviromena team to connect Medebridge to the UK grid to facilitate the delivery of this power to the University via a sleeving arrangement.   

Richard Sullivan, Managing Director of I&C and Estate Intensive at Inspired, said: “CPPAs are an increasingly popular choice for organisations seeking to decarbonise as they offer up to 100% renewable power and much-needed additionality to the grid. Now a solar farm in Essex supplies The University of Manchester with renewable energy. 

“This is the culmination of years of meticulous contract negotiations and support our technical experts have provided, and we are delighted for the project to have reached this point. We look forward to powering our partnership on with The University of Manchester and Enviromena alike.” 

Following a successful tender bid in 2025, The University of Manchester has also extended its procurement contract with Inspired to 2030, providing energy security and ongoing CPPA in-life management. 

EDF, Britain’s largest buyer of renewable electricity, is playing a key role in delivering and running the agreement that enables renewable electricity from Enviromena to power The University of Manchester. As part of this CPPA, EDF takes the variable output from the solar farm and turns it into steady, predictable blocks of power before adding it to the University’s energy supply contract. This ensures a smooth and reliable supply of renewable electricity, while delivering the transparency, reliability and carbon savings the University expects from a major renewable energy initiative.

Tom Abbott, PPA Director at EDF, said: “We’re proud to help The University of Manchester turn its sustainability ambitions into reality. By bringing power from Medebridge Solar Farm through this tailored CPPA, we’re showing how smart partnerships can unlock big wins for decarbonisation. Our balancing, shaping, and sleeving services mean the University gets dependable clean power - and a clear path towards its net zero goals.”

The Medebridge partnership adds to the University’s growing portfolio of environmental and sustainability initiatives from big changes, such as ending all investments in fossil fuels, and completing three zero carbon buildings, to the smaller ones, such as placing food waste bins in every University building, using peat free compost across campus and the .

The University of Manchester was recently ranked in first place in the UK and Europe and second in the world for benefitting society and the environment by  for the third year running and was chosen to lead a pioneering global programme by United Nations designed to empower education’s role in the transition towards net zero.

Published in the American Association of Cancer Research (AACR) journal Cancer Research Communications, the study assessed AOA’s novel technology that analysed multiple groups of biological markers from a single blood sample. 

The researchers showed the test outperformed traditional biomarker tests for ovarian cancer detection in over 950 patients from Colorado and Manchester. 

This study is a major milestone and AOA is committed to pursuing regulatory approval across the US and Europe in the coming years, ahead of launching the test to the NHS. 

The technology combines two different sets of blood-markers, proteins and lipids, with   machine learning to identify the presence of ovarian cancer in women that present with vague abdominal/pelvic symptoms. 

In samples from University of Colorado the test exhibited an accuracy of 93% across all stages of ovarian cancer and 91% for early-stage disease. 

In a set from Manchester, the model continued to perform strongly, with an accuracy of 92% for all-stages of ovarian cancer and 88% for early-stage disease.

 AOA’s test performed better than single blood-based-markers which have been used for the past 30 year, which were only able to attain accuracies of less than 90%. 

The successful results, say AOA, will inform the final design of the test, which could produce a streamlined and cost-effective diagnostic relevant to healthcare systems globally. 

“Our platform detects ovarian cancer at early stages and with greater accuracy than current tools,” said Alex Fisher COO and Co-Founder of AOA Dx. “These findings show its potential to aid clinicians in making faster, more informed decisions for women who need urgent clarity during a challenging diagnostic process.” 

“By using machine learning to combine multiple biomarker types, we’ve developed a diagnostic tool that detects ovarian cancer across the molecular complexity of the disease in sub-types and stages” said Dr. Abigail McElhinny, Chief Science Officer of AOA Dx. “This platform offers a great opportunity to improve the early diagnosis of ovarian cancer potentially resulting in better patient outcomes and lower costs to the healthcare system.”

varian cancer is the fifth leading cause of cancer-related deaths among women, largely due to late-stage diagnosis.

Over 90% of women experience symptoms in Stage I, yet only 20% of cases are diagnosed in Stage I or II, as symptoms like bloating, abdominal pain, and digestive issues often resemble benign conditions.

Existing diagnostic methods, which rely on invasive procedures or less reliable markers, frequently fail to identify early-stage disease.

An accurate early detection test available to women when they first visit a physician with symptoms could revolutionize the detection of ovarian cancer.

Professor Emma Crosbie, Professor at The University of Manchester and Honorary Consultant in Gynecological Oncology, Manchester University NHS Foundation Trust (MFT), said: “AOA Dx’s platform shows significant promise for ovarian cancer early detection, offering a practical solution for symptomatic women.”

Professor Crosbie is also National Institute for Health and Care Research (NIHR) Manchester Biomedical Research Centre (BRC) Cancer Prevention and Early Detection Co-Theme Lead.

She added: “AOA Dx’s platform has the potential to significantly improve patient care and outcomes for women diagnosed with ovarian cancer. We are eager to continue advancing this important research through additional prospective trials to further validate and expand our understanding of how this could be integrated into existing healthcare systems.”

The paper Utilizing serum-derived lipidomics with protein biomarkers and machine learning for early detection of ovarian cancer in the symptomatic population published in cancer Research Communications is available DOI:

The University of Manchester is globally renowned for its pioneering research, outstanding teaching and learning, and commitment to social responsibility. We are a truly international university – ranking in the top 50 in a range of global rankings – with a diverse community of more than 44,000 students, 12,000 staff and 550,000 alumni from 190 countries.  Sign up for our e-news to hear first-hand about our international partnerships and activities across the globe. 

A series of three new papers published this week in Nature Astronomy and Nature Geoscience, reveal that Bennu is a mix of dust formed in our solar system, organic matter from interstellar space and stardust that predates the solar system itself. The asteroid is thought to have formed from fragments of a larger parent asteroid destroyed by a collision in the asteroid belt between the orbits of Mars and Jupiter.

In the first paper, co-led by researchers at the University of Arizona and NASA’s Johnson Space Center, published in the journal , Manchester researchers studied the gases trapped inside Bennu’s samples – in particular xenon, which is a very rare gas. Their measurements showed that Bennu’s gases resembled those found in some of the most primitive meteorites found on earth and materials returned from asteroid Ryugu by Japan’s Hayabusa2 mission.

When combined with other elemental and isotopic analyses, the results suggest that Bennu’s parent body contained material from a range of origins, close to the Sun, far from the Sun, and even some grains from beyond our solar system.

The findings also show that while much of the materials in the parent asteroid had been affected by water and heat, some of the material had escaped various chemical processes and retained its original chemical signatures. Some even survived the extremely energetic collision that broke it apart and formed Bennu.

The studies also show that while some of Bennu’s original material survived unchanged, similarly, much of it was transformed by reactions with water. Minerals in its parent asteroid likely formed, dissolved, and re-formed over time, with up to 80% of Bennu’s material now made up of water-bearing minerals.

These findings were reported in a second paper the paper published in co-led by the University of Arizona and the Smithsonian’s National Museum of Natural History, and included contributions from Professor Rhian Jones at The University of Manchester.

In the third paper, co-led by Lindsay Keller at NASA’s Johnson Space Center and Michelle Thompson of Purdue University, also published in , researchers found microscopic craters and tiny splashes of once-molten rock – known as impact melts – on the sample surfaces - signs that the asteroid was bombarded by micrometeorites. These impacts, together with the effects of solar wind, are known as space weathering and occurred because Bennu has no atmosphere to protect it.

Lindsay Keller at NASA’s Johnson Space Center, said: “The surface weathering at Bennu is happening a lot faster than conventional wisdom would have it, and the impact melt mechanism appears to dominate, contrary to what we originally thought.

“Space weathering is an important process that affects all asteroids, and with returned samples, we can tease out the properties controlling it and use that data and extrapolate it to explain the surface and evolution of asteroid bodies that we haven’t visited.”

As leftovers from the formation of planets 4.5 billion years ago, asteroids like Bennu provide a valuable record of solar system history. Unlike meteorites that fall to Earth, which often burn up or are altered in the atmosphere, Bennu’s pristine samples give scientists a rare opportunity to study untouched material.

The project brings together researchers from NASA, universities and research centres around the world – including the UK, the United States, Japan and Canada – to study Bennu’s samples and unlock new insights into the origins of the solar system.

For more information on NASA’s OSIRIS-REx mission, visit:

Tropi����Ů�� is already partnering with farmer cooperatives representing over 200,000 farmers across East and West Africa, while building high-level collaborations with Innovate UK, the United Nations, and government organisations across the continent. From coffee and cocoa to cashew nuts, sesame seeds, and tropical fruits, Tropi����Ů�� is positioning itself as the go-to gateway for sourcing Africa’s finest agricultural products in one trusted platform. Leveraging AI and blockchain technology, the platform ensures traceability, competitive pricing,and efficient trade facilitation.

The company’s close ties with the University of Manchester’s innovation ecosystem have been instrumental in its growth. Support from the University’s R&D collaborations, has strengthened Tropi����Ů��’s ability to scale and innovate.

For more information, visit or

Alliance Medical has signed a long-term lease agreement to take up residence at the Wolfson Molecular Imaging Centre (WMIC), a University research facility based on the site of the Christie Hospital in Withington, a cancer care, research and education hub. WMIC is home to state-of-the-art radiochemistry facilities, including a cyclotron.

Through the partnership both parties will work collaboratively, combining the academic expertise at the University with Alliance Medical’s extensive industry experience. Alliance Medical works with the NHS to offer PET-CT diagnostic procedures to over one hundred thousand cancer patients in England per year, while also working within the fields of paediatrics, urology and neurology, among others.

Alliance will invest around £10m in the facility to rebuild a state-of-the-art radiopharmacy, which will support future academic research cooperations.

Professor Allan Pacey, Deputy Vice President and Deputy Dean of the Faculty of Biology, Medicine and Health at The University of Manchester said: “We are delighted to have entered into this agreement with Alliance. This will open the doors for new and exciting research opportunities for our staff involved in finding new ways to detect and treat cancers and other medical conditions where radiotracers are important tools.”

Professor Stavros Stivaros, Director of Imaging at The University of Manchester said: “This is an exciting collaborative long-term working agreement, which will revitalise the University’s opportunities for state-of-the-art radiochemistry-based research. Research that spans from pre-clinical right through to diagnostics and therapies, across all age groups of patients.”

As manufacturers of radiotracers, Alliance Medical has production facilities across Europe but its partnership with the University paves the way for a presence in Manchester, a renowned UK medical research hotspot. The University will in turn benefit from Alliance Medical’s significant investment in research activity and the upgrade of its radiochemistry production facilities.

Howard Marsh, Chief Financial Officer for Alliance Medical Group, said: “We are delighted to be working with The University of Manchester to add an additional facility into our network that benefits patients in Manchester and the surrounding areas.”

Axel Schmidt, Managing Director of Alliance Medical Radiopharmacy said: “This cooperation is another testament to the fast-growing field of, and interest in, radiopharmaceuticals. It will further expand our involvement in the development and commercialization of own- and third-party innovative tracers for oncology, neurology and cardiology.”

The University will also utilise local access to commercial radiotracers for preclinical and clinical PET-MR imaging research. With Alliance Medical beginning its operations on the site in Autumn 2025, it is hoped production of radiotracers will begin within two years, with these tracers to be delivered to hospitals to improve patient care and diagnostic offerings.

The research, published today in , tracks 130 years of changes in the “spirograph” Planetary Nebula IC418 - a glowing shell of gas and dust cast off by a dying star about 4000 light years from Earth.

By piecing together observations dating back to 1893, when astronomers first recorded the nebula by eye through a telescope, to today, scientists found the nebula’s signature green light, emitted by oxygen atoms, has grown around 2.5 times stronger since Victorian astronomers first studied it.

This change is being driven by the central star’s rising temperature, which has increased by around 3,000°C since 1893, or roughly 1,000°C every 40 years. For comparison, the Sun increased by the same amount during its formation, but took 10 million years to do it.

However, although the star is heating faster than ever observed, it is still slower than the latest models had predicted. This challenges current theories of how stars age and die, and may force astronomers to rethink the masses of stars capable of producing carbon — the element essential for life.

A planetary nebula marks one of the final stages in a star’s life. As the star’s core becomes unstable, it sheds its outer layers into space. The remaining core heats rapidly, energising the surrounding gas and dust to form beautiful structures. In the case of IC418, this creates an intricate, swirling structure, earning its nickname “the spirograph nebula”. Our Sun will undergo the same fate in about 5 billion years.

While planetary nebulae usually evolve slowly, the researchers discovered that IC418 is evolving fast enough to track within a human lifetime.

This makes it the most prolonged and rapid transformation ever recorded in a planetary nebula, and possibly any star.

The team examined 130 years of observations from a wide range of telescopes – from the human eye measurements in the late 1800s to the advanced technologies of today. They verified, calibrated, and combined the data before comparing it with detailed models of stellar evolution. This allowed them to measure the star’s heating rate, determine its current mass, and even estimate the mass of the star before it began its transformation.

The findings offer a rare insight into of how planetary nebulae evolve and suggest the night sky can change much faster than we usually think.

Co-author, Professor Quentin Parker from the University of Hong Kong, said: “We believe this research is important because it offers unique, direct evidence of how planetary nebulae central stars evolve. It will prompt us to rethink some of our existing models of stellar life cycles.

“It’s been a strong joint effort - collecting, verifying, and carefully analysing more than a century’s worth of astronomical data and then melding that with stellar evolutionary models. It’s a challenging process that goes far beyond simple observation, and we’re grateful for the opportunity to contribute to our field in this way.”

Journal: The Astrophysical Journal Letters

Full title: The secular evolution of planetary nebula IC 418 and its implications for carbon star formation

DOI: 10.3487/2041-8213/ADF62b

Link:

The research also suggests that monks kept their copy of the charter safe for generations, possibly consulting it at annual rent payments or during disputes – ensuring the king’s message lived on.

By looking at this 1,100-year-old parchment not just as a legal record but as a piece of political theatre, the study opens a new window into how early English kings built and maintained their power.

The full article, ‘’, is published in the Journal of Medieval History.

The University of Manchester is globally renowned for its pioneering research, outstanding teaching and learning, and commitment to social responsibility. We are a truly international university – ranking in the top 50 in a range of global rankings – with a diverse community of more than 44,000 students, 12,000 staff and 550,000 alumni from 190 countries.  Sign up for our e-news to hear first-hand about our international partnerships and activities across the globe. 

The company is a spinout from the University of Manchester, founded by Dr Tim Echermeyer, based at the Graphene Engineering Innovation Centre (), and joined by Dr Steve Turley as executive-Chair.

PhovIR uses its breakthrough Near Infra-Red (NIR) optical sensor technology to identify the ‘optical fingerprint’ of constituents of solids, liquids and gases, in a portable device. Human eyes perceive a very narrow band of the optical spectrum, predominantly colours, yet there is much more information about materials and substances contained in longer wavelengths.

This innovation is a ‘platform technology’ which has far-reaching applications for human health, such as the detection of drink spiking and other contaminants to industrial safety, pollution monitoring and agricultural functions.

Although other NIR sensor devices exist, they are bulky, often difficult to integrate into portable devices and expensive to manufacture. The breakthrough achieved by PhovIR allows this to be manufactured on a silicon chip enabling a small, light and cost-effective solution that has the potential to be incorporated into a smart watch or phone.

PhovIR has developed a capability based on MEMS (Micro-Electro-Mechanical Systems) technology to create a flexible, portable, low-cost solution that captures a broader optical range. Its software is fully configurable, doing the job of multiple sensors, and can be manufactured at scale.

Professor Duncan Ivison, President and Vice-Chancellor at The University of Manchester said: “PhovIR is a fantastic example of the kind of innovation that defines The University of Manchester – world-class research brought to life through collaboration, with the potential to change lives.

“It’s exciting to see this deeptech breakthrough moving towards real-world application, supported by the expertise of our Innovation Factory and partners like Northern Gritstone. My congratulations to the team behind PhovIR, this is exactly the kind of impact we want to see more of across our University and our region.”

PhovIR is chaired by Dr Steve Turley, who has over 25 years’ experience dedicated to scaling complex technologies into high growth businesses, including as Chair of Effect Photonics and ex-CEO of Perpetuum.

With the funding, PhovIR plans to bring its first commercial product to market, grow its team, and continue delivering on its vision for making the invisible visible to improve human and planetary health.

PhovIR recently completed Northern Gritstone’s pre-seed program, NG Studios, which has supported PhovIR to refine its commercial strategy as a customer-led organisation ready for growth and successful fundraising.

Active since May 2022, Northern Gritstone has already made 37 investments in early-stage businesses in the North of England, expanded its investment team and built NG Innovation Services, its venture building ‘toolkit’ offering, inter alia: talent management; growth advice; business services; and the accelerator program, NG Studios.

Duncan Johnson, CEO of Northern Gritstone, said: “PhovIR is a Northern Gritstone NG Studios graduate. The University of Manchester is home to innovation in materials science including graphene. Northern Gritstone is delighted to back Dr Tim Echtermeyer and Dr Steve Turley – graduates of our NG Studios venture building program - knowing that PhovIR’s technology has the potential to create a global company.”

Dr Tim Echtermeyer, CTO of PhovIR, said: “I am exhilarated to enter the next part of PhovIR’s journey and turn our vision into reality. I am grateful to the many people contributing and making this happen; particularly Steve, and William Wren and Minh Vu from the Engineering team, who have worked relentlessly.

Dr Steve Turley, Chair of PhovIR said: “I am very excited to be working with PhovIR not only because of the immense potential that the technology has but also the great team in Manchester led by Tim. It’s an opportunity to demonstrate that the UK can take excellent innovative technology and turn it into a global success story”

John Williams, General Partner of SCVC said: “PhovIR represents the future of deep tech: advanced hardware, unlocked by AI. It’s the kind of multi-tech breakthrough that creates entirely new categories—and the kind SCVC is here to back.”

Published today  in the journal , the study provides a major insight into the muscular dystrophy subtype known collectively as Collagen VI-related dystrophy – or COL6-RD for short.

The team are the first ever to determine the high resolution structure of collagen VI- one of the networks of protein molecules that give our tissues mechanical strength and the ability to stretch and bend.

Called the extracellular matrix, the protein network also enables cells to sense their environment and communicate with one another in response to mechanical forces.

COL6-RD, which includes Ullrich congenital muscular dystrophy (UCMD) and  Bethlem myopathy (BM), can cause a range of symptoms including muscle weakness, joint contractures, decreased muscle tone, and weak breathing muscles.

It is one of a number muscular dystrophy subtypes and others include the more prevalent Duchenne-  caused by mutation of another protein -   for which scientists are developing gene therapies.

However, so far equivalent therapies have not been developed for COL6-RD.

Collagens are the most abundant extracellular matrix proteins, and form long fibres many times smaller than a human hair, called microfibrils. 

Collagen VI forms one type of microfibril, taking on the appearance of a large bead-like structure, consisting of  three separate protein chains, that twist and fold together.

The research required the scientists to develop small fragments of collagen VI, which they called mini-collagens.

Mini-collagens will be useful tools for studying or even treating the diseases associated with collagen VI mutations.

Lead author of Biotechnology and Biological Sciences Research Council funded study Clair Baldock, Professor of  Biochemistry at the University of Manchester said: “It is extremely important to understand where mutations in the tiny protein chains called collagen VI that cause a subtype of muscular dystrophy are, to help in the design of future treatments.

“Using a technique called cryogenic-electron microscopy -  which can magnify collagen VI hundreds of thousands of times-   we were able to determine the organisation of parts of collagen VI and map the disease mutations.

“That provides an opportunity for scientists to design drugs which specifically target the mutations by focusing only on what's broken.

She added: “We are the first group to determine the high resolution structure of collagen VI; until now, no- one has been able to show the locations of these mutations on the collagen VI structure.

“This is an important step along the path of finding ways to treat these types of muscular dystrophy and will provide momentum  to accelerate scientific discovery in this area.

“We hope that our structure will provide vital information to help the scientific community develop treatments, such as gene therapy, for collagen VI-RD.

“This provides some hope to people with muscular dystrophy that one day treatments will be available to improve their quality of life and help them to stay active and independent.”

• The paper Collagen VI microfibril structure reveals mechanism for molecular assembly and clustering of inherited pathogenic mutations is . https://doi.org/10.1038/s41467-025-62923-3

Jean, alongside her late husband Michael, co-founded the Oglesby Charitable Trust in 1992, building a legacy that has touched thousands of lives across the North West and beyond. The University has been privileged to share in that legacy for many decades. Jean’s approach to philanthropy was deeply personal – she wanted to understand the programmes she supported, meet the people leading them, and be certain that her giving would create lasting change.  

Through the Trust, Jean and Michael made transformational contributions to our work – from funding PhD scholarships at the Wolfson Molecular Imaging Centre to advancing pioneering research in cancer and leukaemia, to supporting public health policy and environmental sustainability initiatives. Their leadership and generosity were instrumental in establishing the Manchester Cancer Research Centre’s new home, where world-leading oncology teams are now working to develop personalised cancer treatments that will save and extend lives.   

Jean also enriched the University’s cultural life. Her love of the arts was expressed through the Trust’s support for Manchester Museum initially for the vivarium and followed by support for wider capital projects. This was also demonstrated in the Trust’s commissioning of original artworks for the Martin Harris Centre for Music and Drama, the John Rylands Library, and the Whitworth Art Gallery. These contributions have enhanced our campus as a place to learn, work and be inspired. 

In 2015, Jean and Michael became two of the founding members of the Langworthy Circle of Benefactors, an honour that acknowledges our most significant donors. In 2016, Jean was also honoured with a CBE for services to philanthropy in the North West. But those who knew her will remember her most for her warmth, wisdom, and quiet strength - qualities that left an impression on everyone she met.  

Professor Duncan Ivison, President and Vice-Chancellor, said:  “Jean was a close friend to the University and a force for good. Her compassion and clarity of purpose were extraordinary. She believed deeply in the power of community.  She touched and inspired countless lives – in Manchester and far beyond. Her legacy will live on through the Oglesby Charitable Trust, the causes she championed, the institutions she supported and the communities she cared for so deeply.”  

On behalf of the entire University community, we offer our heartfelt condolences to Jean’s family and friends, and our enduring gratitude for her extraordinary partnership, which will continue to inspire for generations to come. 

“For an institution of our scale and ambition, continued progress on the global stage is both a challenge and an opportunity," Duncan added.

The 2025 ARWU result follows a strong year for Manchester in other leading global rankings - in June, it was named the 35th best university in the world in the QS World University Rankings.

The power of the University’s social and environmental impact has also been recognised on a global scale, being the only university in the top ten in both the QS World University Sustainability Rankings and Times Higher Education Impact Rankings, in recognition of its contribution towards the United Nations’ Sustainable Development Goals (SDGs).

The University’s research strength is further evidenced by the 2021 Research Excellence Framework (REF), in which 93% of research activity was rated either ‘world-leading’ (4*) or ‘internationally excellent’ (3*).

“Manchester has always been a place where world-class research meets real-world impact,” said Vice-President for Research Professor Colette Fagan. “We are proud of our achievements, but even more excited about what lies ahead.”

The full 2025 ARWU list and methodology can be explored at ShanghaiRanking’s .

 Published in the American Journal of Nephrology today (11/08/25), the researchers show that higher levels of  Kidney Injury Molecule-1(KIM-1), a special marker of kidney damage in the blood and urine, are associated with higher risks of mortality and kidney failure, never before have the two been measured together. 

The research follows hot on the heels of their published in the Journal of the American Society of Nephrology last month, which measured 21 markers in blood and urine that reflect key processes driving kidney disease, inflammation, and heart disease. 

From the JASN study , the team pinpointed three standout markers that can predict both how quickly kidney disease will progress and the risk of death. 

Unlike the generic tests used in routine kidney clinics, the markers shine a light on the biological changes, underpinning CKD, that truly drive the disease. By revealing the hidden drivers, the discovery opens the door to new treatments designed to target the disease at its roots. 

Lead author Dr Thomas McDonnell, is both a researcher at The University of Manchester and a kidney doctor at Salford Royal Hospital, part of Northern Care Alliance NHS Foundation Trust. 

He said: “The progression of chronic kidney disease is highly variable between people,  so it’s difficult to predict which patients will progress to kidney failure or worse. 

“But our work raises the prospect of the development of  simple blood or urine tests that could better predict the degree of risk-  invaluable information for doctors and patients. 

“We think that , these models, which are more closely aligned with the underlying biological changes happening in chronic kidney disease, could allow a more tailored approach to the individual needs of patients.”

The researchers analysed the blood and urine of adults with non-dialysis chronic kidney disease from 16 nephrology centres across the UK.

They analysed blood and urine KIM-1 in 2581 patients for the KIM-1 study and looked at all 21 markers of kidney damage, fibrosis, inflammation, and cardiovascular disease together in 2,884 patients for the second

They used statistical analysis  to assess how or if biological signals associated with kidney failure and mortality, and developed risk prediction models.

Because chronic kidney disease can stay stable for years in one person but suddenly worsen in another, doctors find it difficult to identify which patients are most at risk.

Existing blood tests currently only give doctors a partial picture, missing important clues like  inflammation and scar build up. As a result, people with the same CKD stage are often labelled has having the same risk and are given the same treatments.

Dr McDonnell added: “This  discovery may will help doctors identify high-risk patients, so they enact more aggressive interventions, earlier specialist referral, and earlier treatment therapies.

“And by identifying low risk patients, they  would be able to prevent over-treatment.

“Living with chronic kidney disease often means managing fatigue, having limits to what you can and can’t eat, and being consigned to  frequent medical appointments.

“It can be physically and emotionally challenging, but with the appropriate care, it is possible maintain an active and fulfilling life.”

Plasma and Urinary KIM-1 in Chronic Kidney Disease: Prognostic Value, Associations with Albuminuria, and Implications for Kidney Failure and Mortality is published in   doi 10.1159/000547867is 

Biomarkers of kidney failure and all-cause mortality in chronic kidney disease  is published in the  DOI:10.1681/ASN.0000000767

The winner of this year’s Prize will be revealed on the evening of 1 October 2025, where they will be presented with a cheque for £25,000. Each of the five shortlisted authors will receive a cheque for £2,500.

A new study, led by researchers at The University of Manchester, in collaboration with Chester Zoo, found that birds appear to follow Zipf’s Law of Abbreviation (ZLA) – the idea that more frequently used sounds tend to be shorter. This rule, found in all human languages, helps make communication more efficient.

The findings, published in the journal today, offer new insight into how animals communicate and provide a new foundation for researchers exploring whether birds, like humans, shape their vocal signals according to the 'principle of least effort'.

Lead author Dr Tucker Gilman, Senior Lecturer at The University of Manchester said: “In human language, if we say something a lot, we tend to shorten it – like saying ‘TV’ instead of ‘television’. It turns out that the same pattern exists in birdsong.

“We know that birds and humans share similarities in the genes and brain structures involved in learning to communicate but this is the first time we’ve been able to detect a consistent pattern of ZLA across multiple bird species. There’s still a lot more work to be done but this is an exciting development.”

Although previous studies hinted that animal communication might follow ZLA – including in penguins – it has been difficult to find clear evidence of ZLA in birdsong. That’s partly because most birds have much smaller repertoires compared to humans. While humans use thousands of words, birds may only produce a few dozen distinct sounds.

To tackle this, the researchers developed new method for studying ZLA in birdsong that focuses on how often individual birds use certain note types and how long those notes last allowing them to examine communication at an individual rather than population level.

They then applied this method using a new open-source computational tool called ZLAvian, which compares real-world observed patterns to simulated ones to determine if ZLA is present.

Using ZLAvian, the team analysed more than 600 songs from 11 bird populations spanning seven different species. They found that while individual populations didn’t always show clear signs of ZLA, a stronger pattern emerged when the data was combined, showing more frequently used birdsong phrases were shorter on average.

Co-author Dr Rebecca Lewis, Conservation Scientist at Chester Zoo, said: “����Ů��ing ZLA in birdsong is far more complex than in human language. Birds often have very few note types, individuals even within the same species can vary widely in their repertoires, and classifying notes is tricky too. Our research has taught that it’s important to look across a wide range of species when looking for language patterns and we hope ZLAvian will make it easier for other researchers to explore these patterns in  more birds but also other animals in the future.”

The team says that further studies are needed across a broader set of bird species to confirm their findings.

Paper details:

Journal: PLoS Computational Biology

Full title: Does Zipf’s law of abbreviation shape birdsong?

DOI: 10.1371/journal.pcbi.1013228

Link:

The academics for the first time, identified how GPs in England are becoming less engaged with their work — and how these signs often follow one after the other, ultimately leading to the decision to quit.

The study published in and funded by the National Institute for Health and Care Research () School of Primary Care Research (SPCR) and Greater Manchester Patient Safety Research Collaboration (PSRC), helps explain the current GP workforce crisis.

While there is substantial evidence both internationally and within the UK of a growing exodus of GPs, until now we did not fully understand the warning signs or how they are linked.

Of 351 GPs from 57 practices surveyed via an online questionnaire, up to one in three GPs experienced symptoms of burnout (27%) and expressed a moderate to high intention to quit patient care within the next five years (33%).

Also from the study, one in five (19%) GPs reported low job satisfaction, two in five (41%) indicated poor work-life balance, and up to one in four (27%) reported working while unwell over the past year.

Further analysis showed that symptoms of burnout and low job satisfaction were the factors most directly linked to GPs’ intentions to leave their roles, even when other work-related factors were taken into account.

The findings suggest that burnout and job dissatisfaction are key drivers influencing GPs’ decisions to leave patient care within the next five years.

Other signs of work disengagement — such as working while unwell or having a poor work-life balance — were more indirectly linked to quitting, often through their effect on burnout and low job satisfaction.

Lead author Dr Christos Grigoroglou, a health economist from The University of Manchester, said:

“We found that job dissatisfaction and burnout are likely to be immediate signals that GPs are at high risk of quitting direct patient care. Poor work-life balance and working while unwell were also indirectly linked.

“This is why there is an urgent need to address these issues if we are to improve GP retention. If we do not, primary care may face unprecedented difficulties.”

The study authors suggested strategies including fair compensation, professional development, and a supportive work environment as ways to enhance job satisfaction.

Organisational support around time and resources to implement stress management programmes and mental health support could also help improve job satisfaction, reduce burnout, and retain GPs.

Preventative measures such as flexible working and fostering a supportive culture that encourages taking sick leave without stigma could improve work-life balance and reduce the tendency to work when unwell.

Principal investigator, psychologist Professor Maria Panagioti, said: “These findings highlight that GP retention policies should incorporate job satisfaction and wellbeing as core strategies to retain GPs.

“Additionally, improving work-life balance and reducing working while unwell can serve as effective early preventative measures to reduce burnout and job dissatisfaction — and in turn, help retain GPs.”

Associations between burnout and career disengagement factors among general practitioners: a path analysis is available

The University of Manchester has been awarded a major grant to lead a new programme that will transform the lifecycle of graphite in nuclear energy - an essential material for the future deployment of nuclear power.

The award brings together world-leading expertise led by The University of Manchester in collaboration with the Universities of Oxford, Plymouth, and Loughborough.

Nuclear energy is expected to play a central role in the UK’s net zero goals as it emits nearly zero carbon dioxide or other greenhouse gas emissions – but it comes with challenges.

The five-year ENLIGHT programme (Enabling a Lifecycle Approach to Graphite for Advanced Modular Reactors) will develop critical technologies to support the deployment of next-generation nuclear energy technology and will address two of the UK’s most pressing nuclear challenges - securing a sustainable, sovereign supply of nuclear graphite and finding solutions to manage the country’s growing volume of irradiated graphite waste.

The project is supported with an £8.2m grant from UK Research and Innovation’s Engineering and Physical Sciences Research Council (EPSRC), Higher Education Institutions, and around £5m of contributions from industry partners.

The programme of research, collaboration, and skills development aims to secure the UK’s position at the forefront of nuclear innovation and a global leader in advanced reactor technology and clean energy innovation.

Graphite is a critical component in many next-generation Advanced Modular Reactors (AMRs), including High Temperature Gas-cooled Reactors and various Molten Salt Reactor designs - technologies key to achieving the UK’s ambition to deliver 24GW of new nuclear power by 2050.

The material accounts for around one-third of reactor build costs, yet despite its importance, the UK currently relies entirely on imports to meet demand.

With the existing Advanced Gas-cooled Reactor fleet approaching decommissioning by 2028, and more than 100,000 tonnes of irradiated graphite already in storage, ENLIGHT will pioneer new approaches to both recycling legacy material and producing new, sustainable high-performance graphite suitable for future AMRs.

Dr Greg Black, Senior Advisor at the Environment Agency, said: “The Environment Agency look forward to participating as a partner in the ENLIGHT programme. As the environmental regulator for the nuclear industry in England, we consider the ambitions of the ENLIGHT programme on 'sustainable graphite' aligns with our Regulatory and RD&I areas of interest.”

The programme will focus on three strands of work:

• Sustainable Graphite – Developing processes for decontaminating, recycling and reusing irradiated graphite from AMR deployment.
• Graphite Selection & Design – Designing new graphite materials engineered to withstand extreme conditions in AMR environments.
• Graphite Performance – Understanding how these new materials behave in novel AMR conditions to improve its lifespan.

These advances could save the UK up to £2 billion in future waste management costs and offers a pathway to strengthen the UK’s unique position as a global hub for graphite research and innovation.

, Professor of Energy Materials at the University of Oxford will lead theme two around graphite selection and design. He said: “I’m delighted to be leading Theme two (Graphite Selection & Design – Designing new graphite materials engineered to withstand extreme conditions in AMR environments) in this major project.  Materials will contribute to several work packages across the whole activity, and our initial focus will be on novel studies of mechanical damage to support the design and qualification of new nuclear graphites for advanced fission reactors.”

At Loughborough University, researchers are contributing advanced computational modelling to explore how nuclear graphite behaves under extreme conditions.

Senior Lecturer in Materials Modelling at Loughborough University, said: “This will help us predict how and when these critical reactor components may fail, guiding the design of stronger, more reliable materials for the reactors of tomorrow. Our research also supports the reuse and recycling of existing graphite, helping to make future nuclear energy both safer and more sustainable."

The University of Plymouth will bring expertise in the analysis of porous materials, which will play a critical role in evaluating the performance and suitability of repurposed graphite.

, Lecturer in Environmental and Analytical Chemistry at the University of Plymouth, said: “This project is not just about scientific discovery; it's about pioneering sustainable solutions for nuclear energy, turning waste into a valuable resource and bolstering the UK's energy security for decades to come. This consortium embodies a truly cyclical and green approach to nuclear solutions, aiming for a cleaner energy transition and helping to demystify some of the traditional concepts that surround the nuclear industry. Our expertise in analysing the intricate properties of porous materials will be instrumental in ensuring the suitability of repurposed graphite for next-generation nuclear reactors, and we are particularly excited to have the opportunity to grow our relationship with The University of Manchester – and our industrial partners across the nuclear industry – through this initiative.”

ENLIGHT will also focus on skills development to expand the national graphite research community and train the next generation of graphite scientists and engineers essential to the UK's clean energy future.

Home to the and a core partner in the , The University of Manchester is uniquely positioned to lead the ENLIGHT programme. The University brings together cutting-edge facilities from the Irradiated Materials Laboratory and the .

ENLIGHT will also build on Manchester's role in flagship activities and initiatives including, the , the and